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KMID : 0363620110320040083
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Journal of Korean Oriental Medicine
2011 Volume.32 No. 4 p.83 ~ p.99
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Protective Effects of Socheongryong-tang on Elastase-Induced Lung Injury
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Lee Ju-Guan
Yang Soo-Young
Kim Min-Hee
Namgung Uk
Park Yang-Chun
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Abstract
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Objective : This study aimed to evaluate the protective effects of Socheongryong-tang (SCRT) on elastase-induced lung injury.
Materials and Methods: The extract of SCRT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed.
Results: SCRT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, and gene expression of TNF- and IL- in A549 cells. SCRT treatment also revealed the protective effect on elastase-induced COPD mice model. This effect was evidenced via histopathological findings including immunofluoresence stains against elastin, collagen, and caspase 3, and protein level of Cdc2, cyclin B1, and phospho-Erk1/2 in lung tissue.
Conclusion: These data suggest that SCRT has pharmaceutical properties on COPD. This study provides scientific evidence for the efficacy of SCRT for clinical application to patients with COPD.
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KEYWORD
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Socheongryong-tang, chronic obstructive pulmonary disease, A549 cell, elastase
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